Peptide name : Alloferon-1

Source/Organism : Blue blowfly

Linear/Cyclic : Linear

Chirality : Not found

Peptide length: 14

C-terminal modification: Linear

N-terminal modification : Not found

Non-natural peptide information: None

Assay type : Anti-tumor activity assay

Assay time : Not found

Activity : Not found

Cell line : P388

Cancer type : Murine leukemia

Other activity : Not found

Amino acid composition bar chart :

Molecular mass : 1402.4368 Dalton

Aliphatic index : 0.414

Instability index : -20.342

Hydrophobicity (GRAVY) : -0.992

Isoelectric point : 7.1569

Charge (pH 7) : 0.196

Aromaticity : 0

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 1

hydrophobic moment : 0.0169

Missing amino acid : C,R,W,T,P,M,I,E,K,F,D,Y,L,N,A

Most occurring amino acid : H

Most occurring amino acid frequency : 5

Least occurring amino acid : S

Least occurring amino acid frequency : 1

Secondary structure fraction (Helix, Turn, Sheet): (0, 0.4, 0.1)

SMILES Notation: CC(C)[C@H](NC(=O)CNC(=O)[C@@H](N)Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)NCC(=O)O)C(C)C

1 : Chernysh S, et al. Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model. Int Immunopharmacol. 2012; 12:312-4. doi: 10.1016/j.intimp.2011.10.016

Paper title : Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model.

Doi : https://doi.org/10.1016/j.intimp.2011.10.016

Abstract : Alloferons are a group of antiviral and anti-tumor peptides primarily isolated from insects and stimulating cytotoxic activity of natural killer cells in mammals including mice and humans. Alloferon-1 is currently used in the treatment of persistent viral infections; however its anti-tumor potential needs further preclinical assessment. Here we evaluate alloferon-1 anti-tumor activity in DBA/2 mice grafted with syngenic P388 murine leukemia cells. Alloferon-1 was applied alone or in combination with conventional cytotoxic chemotherapy (a mixture of cyclophosphamide, doxorubicin and vincristine). Alloferon-1 monotherapy demonstrated moderate tumoristatic and tumoricidal activities comparable with low dose chemotherapy. When alloferon-1 and the cytotoxic drugs were combined in a regime of pulse immunochemotherapy the combination anti-tumor activity evidently exceeded that of the treatments applied individually.