Peptide name : Aurein-1.2

Source/Organism : Southern bell frog

Linear/Cyclic : Linear

Chirality : L

Peptide length: 13

C-terminal modification: Linear

N-terminal modification : Amidation

Non-natural peptide information: None

Assay type : Not specified

Assay time : Not found

Activity : Not found

Cell line : Not found

Cancer type : Not found

Other activity : Anti-microbial activity; Anti-fungal activity

Amino acid composition bar chart :

Molecular mass : 1480.7458 Dalton

Aliphatic index : 1.276

Instability index : 20.4769

Hydrophobicity (GRAVY) : 0.6692

Isoelectric point : 6.069

Charge (pH 7) : -0.238

Aromaticity : 0.153

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 1.6

hydrophobic moment : -0.841

Missing amino acid : C,R,W,H,Q,T,P,M,Y,N,V

Most occurring amino acid : I

Most occurring amino acid frequency : 3

Least occurring amino acid : G

Least occurring amino acid frequency : 1

Secondary structure fraction (Helix, Turn, Sheet): (0.3, 0.2, 0.4)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)O

1 : Apponyi MA, et al. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004; 25:1035-54. doi: 10.1016/j.peptides.2004.03.006

Paper title : Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.

Doi : https://doi.org/10.1016/j.peptides.2004.03.006

Abstract : Host-defence peptides secreted from the skin glands of Australian frogs and toads, are, with a few notable exceptions, different from those produced by anurans elsewhere. This review summarizes the current knowledge of the following classes of peptide isolated and characterized from Australian anurans: neuropeptides (including smooth muscle active peptides, and peptides that inhibit the production of nitric oxide from neuronal nitric oxide synthase), antimicrobial and anticancer active peptides, antifungal peptides and antimalarial peptides. Other topics covered include sex pheromones of anurans, and the application of peptide profiling to (i). recognize particular populations of anurans of the same species and to differentiate between species, and (ii). investigate evolutionary aspects of peptide formation.