dbacp01808
General Description
Peptide name : BIM SM-1
Source/Organism : BH3-only, Direct activators, BIM analogues
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : IWIAQELRRIGDEFNA
Peptide length: 16
C-terminal modification: Linear
N-terminal modification : Not found
Non-natural peptide information: None
Activity Information
Assay type : Not specified
Assay time : Not found
Activity : Not found
Cell line : Not found
Cancer type : Not found
Other activity : Not found
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 1931.1551 Dalton
Aliphatic index : 1.1
Instability index : 69.25
Hydrophobicity (GRAVY) : -0.256
Isoelectric point : 4.6791
Charge (pH 7) : -1.2332
Aromaticity : 0.125
Molar extinction coefficient (cysteine, cystine): (5500, 5500)
Hydrophobic/hydrophilic ratio : 1.28571428
hydrophobic moment : -0.976
Missing amino acid : C,H,T,P,M,K,S,Y,V
Most occurring amino acid : I
Most occurring amino acid frequency : 3
Least occurring amino acid : W
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0.3, 0.1, 0.3)
SMILES Notation: CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)CC)[C@@H](C)CC
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHHHTHHHHH |
| Chou-Fasman (CF) | EEHHHHEEEHHHHCCC |
| Neural Network (NN) | HHHHHHCCCCCCCCCC |
| Joint/Consensus | HHHHHHCCCCCCCCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Reference
1 : Shawcroft J, et al. Corrigendum/Erratum to "Teens, screens and quarantine; The relationship between adolescent media use and mental health prior to and during COVID-19" [Heliyon 8(7), July 2022 e09898]. Heliyon. 2024; 10:e30236. doi: 10.1016/j.heliyon.2024.e30236
Literature
Paper title : Corrigendum/Erratum to "Teens, screens and quarantine; The relationship between adolescent media use and mental health prior to and during COVID-19" [Heliyon 8(7), July 2022 e09898].
Doi : https://doi.org/10.1016/j.heliyon.2024.e30236
Abstract : [This corrects the article DOI: 10.1016/j.heliyon.2022.e09898.].