dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp01808

General Description

Peptide name : BIM SM-1

Source/Organism : BH3-only, Direct activators, BIM analogues

Linear/Cyclic : Linear

Chirality : L

Sequence Information

Sequence : IWIAQELRRIGDEFNA

Peptide length: 16

C-terminal modification: Linear

N-terminal modification : Not found

Non-natural peptide information: None

Activity Information

Assay type : Not specified

Assay time : Not found

Activity : Not found

Cell line : Not found

Cancer type : Not found

Other activity : Not found

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 1931.1551 Dalton

Aliphatic index : 1.1

Instability index : 69.25

Hydrophobicity (GRAVY) : -0.256

Isoelectric point : 4.6791

Charge (pH 7) : -1.2332

Aromaticity : 0.125

Molar extinction coefficient (cysteine, cystine): (5500, 5500)

Hydrophobic/hydrophilic ratio : 1.28571428

hydrophobic moment : -0.976

Missing amino acid : C,H,T,P,M,K,S,Y,V

Most occurring amino acid : I

Most occurring amino acid frequency : 3

Least occurring amino acid : W

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (0.3, 0.1, 0.3)

SMILES Notation: CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)O)[C@@H](C)CC)[C@@H](C)CC

Secondary Structure :

Method Prediction
GOR HHHHHHHHHHTHHHHH
Chou-Fasman (CF) EEHHHHEEEHHHHCCC
Neural Network (NN) HHHHHHCCCCCCCCCC
Joint/Consensus HHHHHHCCCCCCCCCC

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id : 38807612

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Click Here

CancerPPD2 ID : Not available

Reference

1 : Shawcroft J, et al. Corrigendum/Erratum to "Teens, screens and quarantine; The relationship between adolescent media use and mental health prior to and during COVID-19" [Heliyon 8(7), July 2022 e09898]. Heliyon. 2024; 10:e30236. doi: 10.1016/j.heliyon.2024.e30236

Literature

Paper title : Corrigendum/Erratum to "Teens, screens and quarantine; The relationship between adolescent media use and mental health prior to and during COVID-19" [Heliyon 8(7), July 2022 e09898].

Doi : https://doi.org/10.1016/j.heliyon.2024.e30236

Abstract : [This corrects the article DOI: 10.1016/j.heliyon.2022.e09898.].