dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp01811

General Description

Peptide name : BIM SM-4

Source/Organism : BH3-only, Direct activators, BIM analogues

Linear/Cyclic : Linear

Chirality : L

Sequence Information

Sequence : WIAQELRRIGDEFN

Peptide length: 14

C-terminal modification: Linear

N-terminal modification : Not found

Non-natural peptide information: None

Activity Information

Assay type : Not specified

Assay time : Not found

Activity : Not found

Cell line : Not found

Cancer type : Not found

Other activity : Not found

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 1746.9196 Dalton

Aliphatic index : 0.907

Instability index : 77.7143

Hydrophobicity (GRAVY) : -0.742

Isoelectric point : 4.6791

Charge (pH 7) : -1.2332

Aromaticity : 0.142

Molar extinction coefficient (cysteine, cystine): (5500, 5500)

Hydrophobic/hydrophilic ratio : 1

hydrophobic moment : -1.009

Missing amino acid : C,H,T,P,M,K,S,Y,V

Most occurring amino acid : I

Most occurring amino acid frequency : 2

Least occurring amino acid : W

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (0.2, 0.2, 0.3)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(N)=O)C(=O)O

Secondary Structure :

Method Prediction
GOR HHHHHHHHHTCHHH
Chou-Fasman (CF) CHHHHEEECCCCCC
Neural Network (NN) HHHHHCCCCCCCCC
Joint/Consensus HHHHHCCCCCCCCC

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id : 38807612

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Click Here

CancerPPD2 ID : Not available

Reference

1 : Shawcroft J, et al. Corrigendum/Erratum to "Teens, screens and quarantine; The relationship between adolescent media use and mental health prior to and during COVID-19" [Heliyon 8(7), July 2022 e09898]. Heliyon. 2024; 10:e30236. doi: 10.1016/j.heliyon.2024.e30236

Literature

Paper title : Corrigendum/Erratum to "Teens, screens and quarantine; The relationship between adolescent media use and mental health prior to and during COVID-19" [Heliyon 8(7), July 2022 e09898].

Doi : https://doi.org/10.1016/j.heliyon.2024.e30236

Abstract : [This corrects the article DOI: 10.1016/j.heliyon.2022.e09898.].