dbacp02230
General Description
Peptide name : CA-MA
Source/Organism : Ceropin-Melittin hybrid
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : KWKLFKKIGIGKFLHSAKKF
Peptide length: 20
C-terminal modification: Linear
N-terminal modification : Amidation
Non-natural peptide information: None
Activity Information
Assay type : MTT/MTS assay
Assay time : Not found
Activity : Activity : 10% survival rate at 100 µM
Cell line : SNU-601
Cancer type : Gastric cancer
Other activity : Not found
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 2404.9802 Dalton
Aliphatic index : 0.83
Instability index : -14.995
Hydrophobicity (GRAVY) : -0.31
Isoelectric point : 10.778
Charge (pH 7) : 6.8403
Aromaticity : 0.2
Molar extinction coefficient (cysteine, cystine): (5500, 5500)
Hydrophobic/hydrophilic ratio : 1.22222222
hydrophobic moment : -0.386
Missing amino acid : C,R,Q,T,P,M,E,D,Y,N,V
Most occurring amino acid : K
Most occurring amino acid frequency : 7
Least occurring amino acid : W
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0.5, 0.1, 0.4)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CCCCN)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHHHHHHHHHHHHH |
| Chou-Fasman (CF) | HHHHHHEEEEHHHHHHHCCC |
| Neural Network (NN) | HHHHHHHCCCHHHHHHCCCC |
| Joint/Consensus | HHHHHHHCCCHHHHHHHCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download