dbacp02263
General Description
Peptide name : Caerin 1.6
Source/Organism : Orange thighed treefrog, Australia
Linear/Cyclic : Not found
Chirality : L
Sequence Information
Sequence : GLFSVLGAVAKHVLPHVVPVIAEK
Peptide length: 24
C-terminal modification: Not found
N-terminal modification : Free
Non-natural peptide information: None
Activity Information
Assay type : Not specified
Assay time : Not found
Activity : Not found
Cell line : Not found
Cancer type : Not found
Other activity : Not found
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 2480.9867 Dalton
Aliphatic index : 1.5
Instability index : 30.1208
Hydrophobicity (GRAVY) : 1.1167
Isoelectric point : 8.6056
Charge (pH 7) : 0.9353
Aromaticity : 0.041
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 3
hydrophobic moment : -1.021
Missing amino acid : C,R,W,Q,T,M,D,Y,N
Most occurring amino acid : V
Most occurring amino acid frequency : 6
Least occurring amino acid : F
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0.3, 0.2, 0.4)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | TEEEEHHHHHEEECCEECEEHHHH |
| Chou-Fasman (CF) | EEEEEEHHHHHEEEEEEEECCCCC |
| Neural Network (NN) | CCHHHHHHHHHHCCCCCCCEHHCC |
| Joint/Consensus | CEEEEHHHHHHEECCEEEEECCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID : Not available
Reference
1 : Steinborner ST, et al. New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera. J Pept Sci. 1997; 3:181-5. doi: 10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k
Literature
Paper title : New caerin antibacterial peptides from the skin glands of the Australian tree frog Litoria xanthomera.
Doi : https://doi.org/10.1002/(sici)1099-1387(199705)3:3<181::aid-psc97>3.0.co;2-k
Abstract : The secretion of the skin glands of the 'orange-thighed frog' Litoria xanthomera contains seven peptides. One of these is the know hypotensive peptide caerulein. Two new peptides, caerin 1.6 [GLFSVLGAVAKHVLPHVVPVIAEKL(NH2)], and caerin 1.7 [GLFKVLGSVAKHLLPHVAPVIAEKL(NH2)] show antibacterial properties. Two other peptides lack the first two amino acid residues of caerins 1.6 and 1.7 and show no antibacterial activity. The identification of the peptides in Litoria xanthomera confirms that this species is related to Litoria caerula, Litoria gilleni and Litoria splendida but not as closely as those three species are related to each other.