dbacp02324
General Description
Peptide name : Cecropin 2
Source/Organism : Mediterranean fruit fly
Linear/Cyclic : Not found
Chirality : L
Sequence Information
Sequence : GWLKKIGKKIERVGQHTRDATIQTIGVAQQAANVAATLK
Peptide length: 39
C-terminal modification: Not found
N-terminal modification : Free
Non-natural peptide information: None
Activity Information
Assay type : Not specified
Assay time : Not found
Activity : Not found
Cell line : Not found
Cancer type : Leukemia cancer
Other activity : Anti-bacterial activity
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 4200.845 Dalton
Aliphatic index : 0.976
Instability index : 17.2821
Hydrophobicity (GRAVY) : -0.320
Isoelectric point : 10.565
Charge (pH 7) : 4.8462
Aromaticity : 0.025
Molar extinction coefficient (cysteine, cystine): (5500, 5500)
Hydrophobic/hydrophilic ratio : 1.05263157
hydrophobic moment : -1.115
Missing amino acid : C,P,M,F,S,Y
Most occurring amino acid : A
Most occurring amino acid frequency : 6
Least occurring amino acid : W
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0.3, 0.1, 0.3)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)[C@@H](C)O)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHHHHHHTCCCEHHEEEEEEEHHHHHHHHHHHH |
| Chou-Fasman (CF) | HHHHHHHHHCCEEEECCCEEEEEEEEHHHHHHHHHHCCC |
| Neural Network (NN) | CCHHCCCCCCEHHCCCCCCCCEEEECHHHHHHHHHHHHH |
| Joint/Consensus | HHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHH |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID : Not available
Reference
1 : Rosetto M, et al. Sequences of two cDNA clones from the medfly Ceratitis capitata encoding antibacterial peptides of the cecropin family. Gene. 1993; 134:241-3. doi: 10.1016/0378-1119(93)90100-h
Literature
Paper title : Sequences of two cDNA clones from the medfly Ceratitis capitata encoding antibacterial peptides of the cecropin family.
Doi : https://doi.org/10.1016/0378-1119(93)90100-h
Abstract : Using a back translated oligodeoxyribonucleotide probe, encoding a conserved motif in insect antibacterial peptides, we have isolated two cDNA clones from the medfly, Ceratitis capitata. Sequence determination shows that the cDNAs encode two closely related peptides which are members of the cecropin family.