dbacp02377
General Description
Peptide name : Cepafungin complex
Source/Organism : Culture broth of strain, common, free-living bacterium, **Pseudomonas sp.**
Linear/Cyclic : Cyclic
Chirality : Not found
Sequence Information
Sequence : I-C28H46N4O6,II-C27H44N4O6,III-C26H42N4O6
Peptide length: Not available
C-terminal modification: Cyclic
N-terminal modification : Free
Non-natural peptide information: None
Activity Information
Assay type : Not specified
Assay time : Not found
Activity : Not found
Cell line : P-388
Cancer type : Leukemia cancer
Other activity : Anti-fungal activity; Anti-yeast activity
Physicochemical Properties
Amino Acid Composition Bar Chart : Not available
Molecular mass : Not available
Aliphatic index : Not available
Instability index : Not available
Hydrophobicity (GRAVY) : Not available
Isoelectric point : Not available
Charge (pH 7) : Not available
Aromaticity : Not available
Molar extinction coefficient (cysteine, cystine): Not available
Hydrophobic/hydrophilic ratio : Not available
hydrophobic moment : Not available
Missing amino acid : Not available
Most occurring amino acid : Not available
Most occurring amino acid frequency : Not available
Least occurring amino acid : Not available
Least occurring amino acid frequency : Not available
Structural Information
3D-structure: Not available
Secondary structure fraction (Helix, Turn, Sheet): Not available
SMILES Notation: Not available
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | Not available |
| Chou-Fasman (CF) | Not available |
| Neural Network (NN) | Not available |
| Joint/Consensus | Not available |
Molecular Descriptors and ADMET Properties
Molecular descriptors: Not available
ADMET properties: Not available
Cross Referencing Databases databases
Pubmed Id : 2387772, .
Uniprot : Not available
CancerPPD : Not available
ApIAPDB : Not available
Reference
1 : Shoji J, et al. Isolation of cepafungins I, II and III from Pseudomonas species. J Antibiot (Tokyo). 1990; 43:783-7. doi: 10.7164/antibiotics.43.783
Literature
Paper title : Isolation of cepafungins I, II and III from Pseudomonas species.
Doi : https://doi.org/10.7164/antibiotics.43.783
Abstract : New acylpeptide antibiotics named cepafungins I, II and III were isolated from the culture broth of a strain identified as Pseudomonas sp. These antibiotics are neutral substances, soluble in aqueous alcohols and dimethyl sulfoxide, and show UV maxima at 260.5 nm. The IR spectra indicated these to be peptides. Molecular formulas C28H46N4O6, C27H44N4O6 and C26H42N4O6 for cepafungins I, II and III were indicated by elemental analysis and SI-MS. Cepafungins exhibited inhibitory activity against yeast and fungi, and antitumor activity against P388 leukemia in mice.