Peptide name : Cyclopeptide E (Plant defensin)

Source/Organism : Not found

Linear/Cyclic : Cyclic

Chirality : L

Peptide length: 6

C-terminal modification: Cyclic

N-terminal modification : Not found

Non-natural peptide information: None

Assay type : Not specified

Assay time : Not found

Activity : Not found

Cell line : Not found

Cancer type : Not found

Other activity : Not found

Amino acid composition bar chart :

Molecular mass : 652.7377 Dalton

Aliphatic index : 0.65

Instability index : 62.6683

Hydrophobicity (GRAVY) : 0.4833

Isoelectric point : 5.95

Charge (pH 7) : -0.0425

Aromaticity : 0.333

Molar extinction coefficient (cysteine, cystine): (1490, 1490)

Hydrophobic/hydrophilic ratio : 5

hydrophobic moment : -0.360

Missing amino acid : C,R,W,H,Q,T,M,I,E,K,S,D,N,A,V

Most occurring amino acid : G

Most occurring amino acid frequency : 2

Least occurring amino acid : P

Least occurring amino acid frequency : 1

Secondary structure fraction (Helix, Turn, Sheet): (0.1, 0.5, 0.5)

SMILES Notation: CC(C)C[C@H](NC(=O)CNC(=O)[C@@H]1CCCN1)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O

1 : Wélé A, et al. Two cyclopeptides from the seeds of Annona cherimola. Phytochemistry. 2005; 66:2376-80. doi: 10.1016/j.phytochem.2005.06.011

Paper title : Two cyclopeptides from the seeds of Annona cherimola.

Doi : https://doi.org/10.1016/j.phytochem.2005.06.011

Abstract : Bioassay-guided fractionation of cytotoxic of methanol extract of the seeds of Annona cherimola provided two novel cyclic peptides, cherimolacyclopeptide E (1) and cherimolacyclopeptide F (2), which exhibited significant cytotoxic activity against the KB (human nasopharyngeal carcinoma) cell culture system. The peptide 1 and 2 were elucidated by MS/MS fragmentation experiments using a Q-TOF mass spectrometer equipped with an ESI source, extensive 2D NMR analyses and chemical degradation.