Peptide name : Gramicidin A

Source/Organism : Soil bacterium

Linear/Cyclic : Not found

Chirality : Not found

Peptide length: 15

C-terminal modification: Not found

N-terminal modification : Free

Non-natural peptide information: None

Assay type : Not specified

Assay time : 24h

Activity : Not found

Cell line : Not found

Cancer type : Not found

Other activity : Not found

Amino acid composition bar chart :

Molecular mass : 1811.2164 Dalton

Aliphatic index : 1.946

Instability index : 70.0533

Hydrophobicity (GRAVY) : 2.1067

Isoelectric point : 5.495

Charge (pH 7) : -0.266

Aromaticity : 0.266

Molar extinction coefficient (cysteine, cystine): (22000, 22000)

Hydrophobic/hydrophilic ratio : infinite

hydrophobic moment : 0.0529

Missing amino acid : C,R,H,Q,T,P,M,I,E,K,S,D,Y,F,N

Most occurring amino acid : V

Most occurring amino acid frequency : 4

Least occurring amino acid : G

Least occurring amino acid frequency : 1

Secondary structure fraction (Helix, Turn, Sheet): (0.4, 0.0, 0.8)

SMILES Notation: CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O)C(C)C)C(C)C)C(C)C

1 : Dubos RJ. STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : I. PREPARATION OF THE AGENT. ITS ACTIVITY IN VITRO. J Exp Med. 1939; 70:1-10. doi: 10.1084/jem.70.1.1

Paper title : STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS : I. PREPARATION OF THE AGENT. ITS ACTIVITY IN VITRO.

Doi : https://doi.org/10.1084/jem.70.1.1

Abstract : A Gram-positive, spore-bearing, aerobic bacillus, capable of lyzing the living cells of many Gram-positive microbial species, has been isolated from soil. Cultures of this soil bacillus in peptone media release during autolysis a soluble agent which exerts a bactericidal effect on all the Gram-positive microorganisms so far tested, and inactivates their glucose dehydrogenases. It also inhibits the growth of the susceptible species in culture media. Several of the Gram-positive species undergo lysis when incubated with the bactericidal agent. It appears however, that lysis is only a secondary process, due to the autolytic enzymes of the susceptible cells, and that it follows upon some other primary injury caused by the active agent. The bactericidal agent is ineffective against all the Gram-negative bacilli so far tested.