dbacp04444
General Description
Peptide name : Maculatin 1.3
Source/Organism : Fringed Tree Frog, Australia
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : GLLGLLGSVVSHVVPAIVGHF
Peptide length: 21
C-terminal modification: Linear
N-terminal modification : Amidation
Non-natural peptide information: None
Activity Information
Assay type : Not specified
Assay time : Not found
Activity : IC50 : 10−5 to 10−6 M
Cell line : Not specified
Cancer type : Leukaemia
Other activity : Not found
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 2071.4636 Dalton
Aliphatic index : 1.666
Instability index : 14.8429
Hydrophobicity (GRAVY) : 1.6238
Isoelectric point : 6.9177
Charge (pH 7) : -0.0656
Aromaticity : 0.047
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 4.25
hydrophobic moment : -1.194
Missing amino acid : C,R,W,Q,T,M,E,K,D,Y,N
Most occurring amino acid : V
Most occurring amino acid frequency : 5
Least occurring amino acid : P
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0.2, 0.3, 0.5)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)O)C(C)C
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | TEEEEEEEEEEEEEEEEEEEE |
| Chou-Fasman (CF) | CCCEEEEEEEEEEEEEEECCC |
| Neural Network (NN) | CCEEECCCEEECCCEEEEECC |
| Joint/Consensus | CCEEEEEEEEEEEEEEEEECC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID : Not available
Reference
1 : Apponyi MA, et al. Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance. Peptides. 2004; 25:1035-54. doi: 10.1016/j.peptides.2004.03.006
Literature
Paper title : Host-defence peptides of Australian anurans: structure, mechanism of action and evolutionary significance.
Doi : https://doi.org/10.1016/j.peptides.2004.03.006
Abstract : Host-defence peptides secreted from the skin glands of Australian frogs and toads, are, with a few notable exceptions, different from those produced by anurans elsewhere. This review summarizes the current knowledge of the following classes of peptide isolated and characterized from Australian anurans: neuropeptides (including smooth muscle active peptides, and peptides that inhibit the production of nitric oxide from neuronal nitric oxide synthase), antimicrobial and anticancer active peptides, antifungal peptides and antimalarial peptides. Other topics covered include sex pheromones of anurans, and the application of peptide profiling to (i). recognize particular populations of anurans of the same species and to differentiate between species, and (ii). investigate evolutionary aspects of peptide formation.