dbacp04610
General Description
Peptide name : Maximin1
Source/Organism : Yunnan firebelly toad
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : GIGTKILGGVKTALKGALKELASTYAN
Peptide length: 27
C-terminal modification: Linear
N-terminal modification : Amidation
Non-natural peptide information: None
Activity Information
Assay type : MTT/MTS assay
Assay time : 48h
Activity : IC50 : 35.4 µg/ml
Cell line : T-24
Cancer type : Bladder cancer
Other activity : Anti-microbial activity; Spermicidal action; Anti-HIV activity
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 2675.128 Dalton
Aliphatic index : 1.122
Instability index : 7.0259
Hydrophobicity (GRAVY) : 0.2519
Isoelectric point : 9.8256
Charge (pH 7) : 2.7579
Aromaticity : 0.037
Molar extinction coefficient (cysteine, cystine): (1490, 1490)
Hydrophobic/hydrophilic ratio : 1.45454545
hydrophobic moment : -1.078
Missing amino acid : C,R,W,H,Q,P,M,F,D
Most occurring amino acid : G
Most occurring amino acid frequency : 5
Least occurring amino acid : V
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0.4, 0.2, 0.4)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)CN)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)O)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)[C@@H](C)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | CCEEEEETCEHHHHHHHHHHHHHHHTT |
| Chou-Fasman (CF) | EEEEEEEEEEHHHHHHHHHHEEEECCC |
| Neural Network (NN) | CCCCEEECCCHHHHHHHHHHHHHHCCC |
| Joint/Consensus | CCEEEEECCCHHHHHHHHHHHHHHCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Reference
1 : Lai R, et al. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. Peptides. 2002; 23:427-35. doi: 10.1016/s0196-9781(01)00641-6
Literature
Paper title : Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima.
Doi : https://doi.org/10.1016/s0196-9781(01)00641-6
Abstract : Two groups of antimicrobial peptides have been isolated from skin secretions of Bombina maxima. Peptides in the first group, named maximins 1, 2, 3, 4 and 5, are structurally related to bombinin-like peptides (BLPs). Unlike BLPs, sequence variations in maximins occurred all through the molecules. In addition to the potent antimicrobial activity, cytotoxicity against tumor cells and spermicidal action of maximins, maximin 3 possessed a significant anti-HIV activity. Maximins 1 and 3 were toxic to mice with LD(50) values of 8.2 and 4.3 mg/kg, respectively. Peptides in the second group, termed maximins H1, H2, H3 and H4, are homologous with bombinin H peptides. cDNA sequences revealed that one maximin peptide plus one maximin H peptide derived from a common larger protein.