dbacp04850
General Description
Peptide name : Nisin ZP
Source/Organism : Not found
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : ITSISLCTPGCKTGALMGCnMKTATCNCSIHVSK
Peptide length: 34
C-terminal modification: Linear
N-terminal modification : Not found
Non-natural peptide information: None
Activity Information
Assay type : Not specified
Assay time : Not found
Activity : Not found
Cell line : HNSCC
Cancer type : Not specified
Other activity : Not found
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 3475.1558 Dalton
Aliphatic index : 0.717
Instability index : 17.0824
Hydrophobicity (GRAVY) : 0.4059
Isoelectric point : 8.7803
Charge (pH 7) : 2.7948
Aromaticity : 0
Molar extinction coefficient (cysteine, cystine): (0, 250)
Hydrophobic/hydrophilic ratio : 1.35714285
hydrophobic moment : -0.069
Missing amino acid : R,W,Q,E,F,D,Y
Most occurring amino acid : T
Most occurring amino acid frequency : 5
Least occurring amino acid : P
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0.2, 0.2, 0.3)
SMILES Notation: CC[C@H](C)[C@H](N)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)[C@@H](C)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | EEEEEEECTTCCCTCEETCCCTTTCTTTTEEETT |
| Chou-Fasman (CF) | EEEEEECCCEECCCCCCCHHHHCCCCEEEEECCC |
| Neural Network (NN) | EEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCC |
| Joint/Consensus | EEEEEECCCCCCCCCCCCCCCCCCCCCCCEECCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID : Not available
Reference
1 : Chivu RF, et al. The Role of Helicobacter Pylori Infection in the Development of Gastric Cancer - Review of the Literature. Chirurgia (Bucur). 2024; 119:1-10. doi: 10.21614/chirurgia.119.eC.2971
Literature
Paper title : The Role of Helicobacter Pylori Infection in the Development of Gastric Cancer - Review of the Literature.
Doi : https://doi.org/10.21614/chirurgia.119.eC.2971
Abstract : Helicobacter pylori (H. pylori), classified as a Group 1 carcinogen by the International Agency for Research on Cancer (IARC), is linked to gastric cancer. The progression from atrophy to metaplasia, dysplasia, and carcinoma constitutes the pathway for intestinal-type gastric carcinoma development. H. pylori infection significantly increases gastric cancer risk, particularly in individuals with atrophic gastritis. Virulence factors like CagA and VacA disrupt host signaling pathways, contributing to chronic inflammation and carcinogenesis. Pro-inflammatory cytokines and dysregulated tumor suppressor genes further fuel this process. Eradicating H. pylori reduces gastric cancer incidence, especially in patients with atrophic gastritis and/or intestinal metaplasia. However, it may not prevent cancer in those with advanced pre-neoplastic lesions. Early detection and management of H. pylori infection are crucial in mitigating gastric cancer risk, offering significant benefits.