dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp05564

General Description

Peptide name : Piscidin 1

Source/Organism : Mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Striped bass x White bass)

Linear/Cyclic : Not found

Chirality : L

Sequence Information

Sequence : FFHHIFRGIVHVGKTIHRLVTG

Peptide length: 22

C-terminal modification: Not found

N-terminal modification : Free

Non-natural peptide information: None

Activity Information

Assay type : Not specified

Assay time : Not found

Activity : Not found

Cell line : Not found

Cancer type : Breast cancer

Other activity : Not found

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 2572.0227 Dalton

Aliphatic index : 1.104

Instability index : 8.1136

Hydrophobicity (GRAVY) : 0.4545

Isoelectric point : 12

Charge (pH 7) : 3.1078

Aromaticity : 0.136

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 1.44444444

hydrophobic moment : 0.8676

Missing amino acid : C,W,Q,P,M,E,S,D,Y,N,A

Most occurring amino acid : H

Most occurring amino acid frequency : 4

Least occurring amino acid : K

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (0.0, 0.1, 0.5)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(C)C

Secondary Structure :

Method Prediction
GOR HHHHHHHEEEEETEEEEEEEET
Chou-Fasman (CF) CEEEEEEEEEEEEEEEEEECCC
Neural Network (NN) HHEECCCEEEEECCCEEEEEEC
Joint/Consensus CCEECCCEEEEEEEEEEEEEEC

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id : 11713517

Uniprot : Not available

PDB : 2JOS

CancerPPD : Not available

ApIAPDB : Not available

CancerPPD2 ID : Not available

Reference

1 : Silphaduang U and Noga EJ. Peptide antibiotics in mast cells of fish. Nature. 2001; 414:268-9. doi: 10.1038/35104690

Literature

Paper title : Peptide antibiotics in mast cells of fish.

Doi : https://doi.org/10.1038/35104690

Abstract : Not available