dbacp05564
General Description
Peptide name : Piscidin 1
Source/Organism : Mainly mast cells, gill, skin, intestine, spleen, and anterior kidney, hybrid striped bass (Striped bass x White bass)
Linear/Cyclic : Not found
Chirality : L
Sequence Information
Sequence : FFHHIFRGIVHVGKTIHRLVTG
Peptide length: 22
C-terminal modification: Not found
N-terminal modification : Free
Non-natural peptide information: None
Activity Information
Assay type : Not specified
Assay time : Not found
Activity : Not found
Cell line : Not found
Cancer type : Breast cancer
Other activity : Not found
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 2572.0227 Dalton
Aliphatic index : 1.104
Instability index : 8.1136
Hydrophobicity (GRAVY) : 0.4545
Isoelectric point : 12
Charge (pH 7) : 3.1078
Aromaticity : 0.136
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 1.44444444
hydrophobic moment : 0.8676
Missing amino acid : C,W,Q,P,M,E,S,D,Y,N,A
Most occurring amino acid : H
Most occurring amino acid frequency : 4
Least occurring amino acid : K
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0.0, 0.1, 0.5)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)CC)[C@@H](C)O)C(C)C)C(C)C
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHEEEEETEEEEEEEET |
| Chou-Fasman (CF) | CEEEEEEEEEEEEEEEEEECCC |
| Neural Network (NN) | HHEECCCEEEEECCCEEEEEEC |
| Joint/Consensus | CCEECCCEEEEEEEEEEEEEEC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID : Not available
Reference
1 : Silphaduang U and Noga EJ. Peptide antibiotics in mast cells of fish. Nature. 2001; 414:268-9. doi: 10.1038/35104690
Literature
Paper title : Peptide antibiotics in mast cells of fish.
Doi : https://doi.org/10.1038/35104690
Abstract : Not available