dbacp07115
General Description
Peptide name : Galaxamide
Source/Organism : Galaxaura filamentosa
Linear/Cyclic : Cyclic
Chirality : L
Sequence Information
Sequence : (N-Me-L)L(N-Me-L)LL
Peptide length: Not available
C-terminal modification: Cyclic
N-terminal modification : Cyclized
Non-natural peptide information: N-Me-L = N-methyl-Lysine
Activity Information
Assay type : MTT assay
Assay time :
Activity : IC50 = 8.73 ± 0.29 µg/ml
Cell line : MDA-MB-231
Cancer type : Breast Cancer
Other activity : Anticancer
Physicochemical Properties
Amino Acid Composition Bar Chart : Not available
Molecular mass : Not available
Aliphatic index : Not available
Instability index : Not available
Hydrophobicity (GRAVY) : Not available
Isoelectric point : Not available
Charge (pH 7) : Not available
Aromaticity : Not available
Molar extinction coefficient (cysteine, cystine): Not available
Hydrophobic/hydrophilic ratio : Not available
hydrophobic moment : Not available
Missing amino acid : Not available
Most occurring amino acid : Not available
Most occurring amino acid frequency : Not available
Least occurring amino acid : Not available
Least occurring amino acid frequency : Not available
Structural Information
3D-structure: Not available
Secondary structure fraction (Helix, Turn, Sheet): Not available
SMILES Notation: Not available
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | Not available |
| Chou-Fasman (CF) | Not available |
| Neural Network (NN) | Not available |
| Joint/Consensus | Not available |
Molecular Descriptors and ADMET Properties
Molecular descriptors: Not available
ADMET properties: Not available
Cross Referencing Databases databases
Pubmed Id : 35323457.0, .
Uniprot : Not available
CancerPPD : Not available
ApIAPDB : Not available
Reference
1 : Li D, et al. Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents. Mar Drugs. 2022; 20:(unknown pages). doi: 10.3390/md20030158
Literature
Paper title : Synthesis of Marine Cyclopeptide Galaxamide Analogues as Potential Anticancer Agents.
Doi : https://doi.org/10.3390/md20030158
Abstract : In this paper, eight new galaxamide analogues (Z-1~Z-8) were synthesized and evaluated for their cytotoxic activities against five cancer cell lines, MCF-7, MD-MBA-231, HepG2, Hela, and A549, using MTT assays. The modified analogue Z-6 displayed broad spectrum cytotoxic activity toward each tested cell line with IC<sub>50</sub> values of 1.65 ± 0.30 (MCF-7), 2.91 ± 0.17 (HepG2), 4.59 ± 0.27 (MD-MBA-231), 5.69 ± 0.37 (Hela), and 5.96 ± 0.41 (A549) μg/mL, respectively. The galaxamides Z-3 and Z-6 induced concentration-dependent apoptosis of the MCF-7 cells after 72 h as evaluated by the flow cytometry experiment. The results showed that these compounds could induce MCF-7 cell apoptosis by arresting the G0/G1 phase of the cell cycle and finally achieving the effect of inhibiting the proliferation of MCF-7 cells.