dbacp08307
General Description
Peptide name : DAP1
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : LWKRWVGVWRKWL
Peptide length: 13
C-terminal modification: Linear
N-terminal modification : Amidation
Non-natural peptide information:
Activity Information
Assay type : MTT assay
Assay time : 48-h
Activity : IC50 = 11.9 μM
Cell line : A-549
Cancer type : Lung Cancer
Other activity : Antimicrobial
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 1813.1994 Dalton
Aliphatic index : 1.046
Instability index : 93.0154
Hydrophobicity (GRAVY) : -0.369
Isoelectric point : 12
Charge (pH 7) : 3.7581
Aromaticity : 30.76
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 2.25
hydrophobic moment : 0.5024
Missing amino acid : A,C,D,E,F,H,I,M,N,P,Q,S,T,Y
Most occurring amino acid : W
Most occurring amino acid frequency : 4
Least occurring amino acid : G
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (30., 7.6, 61.)
SMILES Notation: CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHHHHHH |
| Chou-Fasman (CF) | CCEEEEEECCCCC |
| Neural Network (NN) | HHHHHHHHHHHHH |
| Joint/Consensus | HHHHHHHHHHHHH |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7784