dbacp08311
General Description
Peptide name : AMP1
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : WKWLKKWIK
Peptide length: 9
C-terminal modification: Linear
N-terminal modification : Amidation
Non-natural peptide information:
Activity Information
Assay type : MTT assay
Assay time : 48-h
Activity : IC50 = 51.1 μM
Cell line : OVCAR-3
Cancer type : Ovarian Cancer
Other activity : Antimicrobial
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 1315.6494 Dalton
Aliphatic index : 0.866
Instability index : 3.7333
Hydrophobicity (GRAVY) : -1.111
Isoelectric point : 10.477
Charge (pH 7) : 3.7561
Aromaticity : 33.33
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 1.25
hydrophobic moment : 0.7249
Missing amino acid : A,C,D,E,F,G,H,M,N,P,Q,R,S,T,V,Y
Most occurring amino acid : K
Most occurring amino acid frequency : 4
Least occurring amino acid : L
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (55., 0, 55.)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHH |
| Chou-Fasman (CF) | HHHHHHCCC |
| Neural Network (NN) | HHHHHHHHC |
| Joint/Consensus | HHHHHHHHC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7788