dbacp08312
General Description
Peptide name : AMP2
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : KRWWKWWRR
Peptide length: 9
C-terminal modification: Linear
N-terminal modification : Amidation
Non-natural peptide information:
Activity Information
Assay type : MTT assay
Assay time : 48-h
Activity : IC50 = 53.5 μM
Cell line : OVCAR-3
Cancer type : Ovarian Cancer
Other activity : Antimicrobial
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 1487.7566 Dalton
Aliphatic index : 0
Instability index : 172.4
Hydrophobicity (GRAVY) : -2.766
Isoelectric point : 12
Charge (pH 7) : 4.7581
Aromaticity : 44.44
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 0.8
hydrophobic moment : -1.064
Missing amino acid : A,C,D,E,F,G,H,I,L,M,N,P,Q,S,T,V,Y
Most occurring amino acid : W
Most occurring amino acid frequency : 4
Least occurring amino acid : K
Least occurring amino acid frequency : 2
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (22., 0, 44.)
SMILES Notation: N=C(N)NCCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHH |
| Chou-Fasman (CF) | CCEECCCCC |
| Neural Network (NN) | HHHHHHHCC |
| Joint/Consensus | HHHHHHHCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7789