dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp08325

General Description

Peptide name : Sample Peptide 6 from US011339203B2

Source/Organism : Synthetic

Linear/Cyclic : Linear

Chirality : L

Sequence Information

Sequence : VIIVLSVFIACWAPLFILLLLKKRTLRKNDRKKR

Peptide length: 34

C-terminal modification: Linear

N-terminal modification : Amidation

Non-natural peptide information:

Activity Information

Assay type : CCK-8 assay

Assay time : 48-h

Activity : Cell Viability = 59.7% at 25 μM

Cell line : CAKI-2

Cancer type : Renal Cancer

Other activity : Anticancer

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 4066.0888 Dalton

Aliphatic index : 1.576

Instability index : 54.1324

Hydrophobicity (GRAVY) : 0.6

Isoelectric point : 11.593

Charge (pH 7) : 7.7202

Aromaticity : 8.823

Molar extinction coefficient (cysteine, cystine): (1, 0)

Hydrophobic/hydrophilic ratio : 1.6154

hydrophobic moment : 0.1437

Missing amino acid : E,G,H,M,Q,Y

Most occurring amino acid : L

Most occurring amino acid frequency : 7

Least occurring amino acid : S

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (41., 11., 52.)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)[C@@H](C)CC)[C@@H](C)CC)C(C)C)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)[C@@H](C)O)[C@@H](C)CC

Secondary Structure :

Method Prediction
GOR EEEEEEEEHHHHCHHHHHHHHHHHHHHHHHHTHH
Chou-Fasman (CF) EEEEEEEEECCCCEEEEHHHHHHCHHHHHHHCCC
Neural Network (NN) EEEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCC
Joint/Consensus EEEEEEEEHHHHCHHHHHHHHHHHHHHHHHHCCC

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id :

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Not available

CancerPPD2 ID: 7821

Reference

Literature