dbacp08341
General Description
Peptide name : Sample Peptide 5 from EP3604345B1
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : KKRTLRKNDRKKR
Peptide length: 13
C-terminal modification: Linear
N-terminal modification : Amidation
Non-natural peptide information:
Activity Information
Assay type : CCK-8 / WST-8
Assay time : 48-h
Activity : Cell Viability = 106.5% at 25 μM
Cell line : HCC-827
Cancer type : Lung Cancer
Other activity : Anticancer
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 1727.0711 Dalton
Aliphatic index : 0.3
Instability index : 68.4
Hydrophobicity (GRAVY) : -3.184
Isoelectric point : 12
Charge (pH 7) : 7.7562
Aromaticity : 0
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 0.0833
hydrophobic moment : 0.575
Missing amino acid : A,C,E,F,G,H,I,M,P,Q,S,V,W,Y
Most occurring amino acid : K
Most occurring amino acid frequency : 5
Least occurring amino acid : T
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (46., 15., 15.)
SMILES Notation: CC(C)C[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHHHTHH |
| Chou-Fasman (CF) | CCCHHHHHHHCCC |
| Neural Network (NN) | CCCHHCCCCCCCC |
| Joint/Consensus | CCCHHHHHHHCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7834