dbacp08342
General Description
Peptide name : VLL-28
Source/Organism : Sulfolobus islandicus
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : VLLVTLTRLHQRGVIYEKWRHFSGRKYR
Peptide length: 28
C-terminal modification: Linear
N-terminal modification : Free
Non-natural peptide information:
Activity Information
Assay type : MTT assay
Assay time : 72-h
Activity : IC50 = 10 μM
Cell line : HEK-293T
Cancer type : Renal Cancer
Other activity : Antibacterial and Anticancer
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 3513.109 Dalton
Aliphatic index : 1.007
Instability index : -1.9786
Hydrophobicity (GRAVY) : -0.539
Isoelectric point : 11.466
Charge (pH 7) : 5.9071
Aromaticity : 14.28
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 0.75
hydrophobic moment : 0.1555
Missing amino acid : A,C,D,M,N,P
Most occurring amino acid : R
Most occurring amino acid frequency : 5
Least occurring amino acid : Q
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (25, 10., 50)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | EEEEEEEEHHETTEHHHHHHHHTTHHHT |
| Chou-Fasman (CF) | EEEEEEECCCEEEEHHHHHCCCCCCCCC |
| Neural Network (NN) | HEHHHHHHHCCCCCEEEHHHCCCCCCCC |
| Joint/Consensus | EEEEEEECCCCCCCHHHHHHCCCCCCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 5713