dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp08342

General Description

Peptide name : VLL-28

Source/Organism : Sulfolobus islandicus

Linear/Cyclic : Linear

Chirality : L

Sequence Information

Sequence : VLLVTLTRLHQRGVIYEKWRHFSGRKYR

Peptide length: 28

C-terminal modification: Linear

N-terminal modification : Free

Non-natural peptide information:

Activity Information

Assay type : MTT assay

Assay time : 72-h

Activity : IC50 = 10 μM

Cell line : HEK-293T

Cancer type : Renal Cancer

Other activity : Antibacterial and Anticancer

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 3513.109 Dalton

Aliphatic index : 1.007

Instability index : -1.9786

Hydrophobicity (GRAVY) : -0.539

Isoelectric point : 11.466

Charge (pH 7) : 5.9071

Aromaticity : 14.28

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 0.75

hydrophobic moment : 0.1555

Missing amino acid : A,C,D,M,N,P

Most occurring amino acid : R

Most occurring amino acid frequency : 5

Least occurring amino acid : Q

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (25, 10., 50)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

Secondary Structure :

Method Prediction
GOR EEEEEEEEHHETTEHHHHHHHHTTHHHT
Chou-Fasman (CF) EEEEEEECCCEEEEHHHHHCCCCCCCCC
Neural Network (NN) HEHHHHHHHCCCCCEEEHHHCCCCCCCC
Joint/Consensus EEEEEEECCCCCCCHHHHHHCCCCCCCC

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id :

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Not available

CancerPPD2 ID: 5713

Reference

Literature