dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp08353

General Description

Peptide name : Seq ID No. 15 from patent ID US202000079827A1

Source/Organism : Synthetic

Linear/Cyclic : Linear

Chirality : L

Sequence Information

Sequence : LKKWWKKVKGLLGGLLGKVTSVIK

Peptide length: 24

C-terminal modification: Linear

N-terminal modification : Free

Non-natural peptide information:

Activity Information

Assay type : Tetrazolium-based assay

Assay time : 2-h

Activity : Cell viability < 50% at 20 μM

Cell line : Calu-1

Cancer type : Lung Cancer

Other activity : Antimicrobial and Anticancer

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 2680.3662 Dalton

Aliphatic index : 1.337

Instability index : -11.237

Hydrophobicity (GRAVY) : 0.1625

Isoelectric point : 10.778

Charge (pH 7) : 6.7531

Aromaticity : 8.333

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 1.6667

hydrophobic moment : 1.6591

Missing amino acid : A,C,D,E,F,H,M,N,P,Q,R,Y

Most occurring amino acid : K

Most occurring amino acid frequency : 7

Least occurring amino acid : T

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (50, 20., 50)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O

Secondary Structure :

Method Prediction
GOR HHHHHHHHTHHETEEEEEEEEEEE
Chou-Fasman (CF) HHHHHHHCCEEEEECEEEEEECCC
Neural Network (NN) HHHHHHHHHHHHCCCCCCCCEEEE
Joint/Consensus HHHHHHHHCCCEEEEEEEEEEEEE

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id :

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Not available

CancerPPD2 ID: 7717

Reference

Literature