dbacp08355
General Description
Peptide name : Seq ID No. 16 from patent ID US202000079827A1
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : LKKWWKKVKGLLGGLLGKVKSVIK
Peptide length: 24
C-terminal modification: Linear
N-terminal modification : Free
Non-natural peptide information:
Activity Information
Assay type : Tetrazolium-based assay
Assay time : 2-h
Activity : Cell viability > 50% at 20 μM
Cell line : NCI-H460
Cancer type : Lung Cancer
Other activity : Antimicrobial and Anticancer
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 2707.4346 Dalton
Aliphatic index : 1.337
Instability index : -8.9
Hydrophobicity (GRAVY) : 0.0292
Isoelectric point : 10.845
Charge (pH 7) : 7.7521
Aromaticity : 8.333
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 1.6667
hydrophobic moment : 1.6823
Missing amino acid : A,C,D,E,F,H,M,N,P,Q,R,T,Y
Most occurring amino acid : K
Most occurring amino acid frequency : 8
Least occurring amino acid : S
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (54., 20., 45.)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHTHHHTEEEHEEEEEEE |
| Chou-Fasman (CF) | HHHHHHHCCEEEEECCCCEEECCC |
| Neural Network (NN) | HHHHHHHHHHHHHHHCCCCCCEEE |
| Joint/Consensus | HHHHHHHHCCCCCCCCCCEEEEEE |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7719