dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp08358

General Description

Peptide name : Seq ID No. 17 from patent ID US202000079827A1

Source/Organism : Synthetic

Linear/Cyclic : Linear

Chirality : L

Sequence Information

Sequence : LKKWWKKVKGLLGGLLGKVKKVIK

Peptide length: 24

C-terminal modification: Linear

N-terminal modification : Free

Non-natural peptide information:

Activity Information

Assay type : Tetrazolium-based assay

Assay time : 2-h

Activity : Cell viability > 50% at 20 μM

Cell line : NCI-H460

Cancer type : Lung Cancer

Other activity : Antimicrobial and Anticancer

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 2748.5296 Dalton

Aliphatic index : 1.337

Instability index : -12.437

Hydrophobicity (GRAVY) : -0.1

Isoelectric point : 10.903

Charge (pH 7) : 8.7511

Aromaticity : 8.333

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 1.6667

hydrophobic moment : 1.8037

Missing amino acid : A,C,D,E,F,H,M,N,P,Q,R,S,T,Y

Most occurring amino acid : K

Most occurring amino acid frequency : 9

Least occurring amino acid : I

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (58., 16., 45.)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)O

Secondary Structure :

Method Prediction
GOR HHHHHHHHTHHHTHHHHHHHHEEE
Chou-Fasman (CF) HHHHHHHCCEEEEECCCCEEECCC
Neural Network (NN) HHHHHHHHHHHHHHHHHHHHHHHH
Joint/Consensus HHHHHHHHCCCCCHHHHHHHHCCC

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id :

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Not available

CancerPPD2 ID: 7722

Reference

Literature