dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp08363

General Description

Peptide name : Seq ID No. 34 from patent ID US202000079827A1

Source/Organism : Synthetic

Linear/Cyclic : Linear

Chirality : Mix

Sequence Information

Sequence : RRWvRRvRRvWRRvvRvvRRWvRR

Peptide length: 24

C-terminal modification: Linear

N-terminal modification : Free

Non-natural peptide information:

Activity Information

Assay type : Tetrazolium-based assay

Assay time : 2-h

Activity : Cell viability > 50% at 20 μM

Cell line : Calu-1

Cancer type : Lung Cancer

Other activity : Antimicrobial and Anticancer

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 3400.1071 Dalton

Aliphatic index : 0

Instability index : 193.441

Hydrophobicity (GRAVY) : -1.15

Isoelectric point : 12

Charge (pH 7) : 12.76

Aromaticity : 12.5

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 0.2308

hydrophobic moment : -0.630

Missing amino acid : A,C,D,E,F,G,H,I,K,L,M,N,P,Q,S,T,V,Y

Most occurring amino acid : R

Most occurring amino acid frequency : 13

Least occurring amino acid : W

Least occurring amino acid frequency : 3

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (0, 0, 45.)

SMILES Notation: CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O

Secondary Structure :

Method Prediction
GOR HHHHHHHHHHHEEEEEEEEEHHHH
Chou-Fasman (CF) EEEEEEEEEEEEEEEEEEEEECCC
Neural Network (NN) HHHEEHHHHEEEEEEEEEEEEEEH
Joint/Consensus CCCEEHHHHEEEEEEEEEEEECCC

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id :

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Not available

CancerPPD2 ID: 7727

Reference

Literature