dbacp08363
General Description
Peptide name : Seq ID No. 34 from patent ID US202000079827A1
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : Mix
Sequence Information
Sequence : RRWvRRvRRvWRRvvRvvRRWvRR
Peptide length: 24
C-terminal modification: Linear
N-terminal modification : Free
Non-natural peptide information:
Activity Information
Assay type : Tetrazolium-based assay
Assay time : 2-h
Activity : Cell viability > 50% at 20 μM
Cell line : Calu-1
Cancer type : Lung Cancer
Other activity : Antimicrobial and Anticancer
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 3400.1071 Dalton
Aliphatic index : 0
Instability index : 193.441
Hydrophobicity (GRAVY) : -1.15
Isoelectric point : 12
Charge (pH 7) : 12.76
Aromaticity : 12.5
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 0.2308
hydrophobic moment : -0.630
Missing amino acid : A,C,D,E,F,G,H,I,K,L,M,N,P,Q,S,T,V,Y
Most occurring amino acid : R
Most occurring amino acid frequency : 13
Least occurring amino acid : W
Least occurring amino acid frequency : 3
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (0, 0, 45.)
SMILES Notation: CC(C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHHHHHHEEEEEEEEEHHHH |
| Chou-Fasman (CF) | EEEEEEEEEEEEEEEEEEEEECCC |
| Neural Network (NN) | HHHEEHHHHEEEEEEEEEEEEEEH |
| Joint/Consensus | CCCEEHHHHEEEEEEEEEEEECCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7727