dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp08376

General Description

Peptide name : IDP-NLCa02

Source/Organism : Synthetic

Linear/Cyclic : Linear

Chirality : L

Sequence Information

Sequence : RQIKIWFQNRRMKWKKRQRRNDLRSSFLTLRDHVP

Peptide length: 35

C-terminal modification: Linear

N-terminal modification : Free

Non-natural peptide information:

Activity Information

Assay type : AlamarBlue assay

Assay time : 72-96 h

Activity : EC50 ~ 5 μM

Cell line : RG1

Cancer type : Glioblastoma

Other activity : Anticancer

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 4595.3531 Dalton

Aliphatic index : 0.64

Instability index : 96.0057

Hydrophobicity (GRAVY) : -1.511

Isoelectric point : 12

Charge (pH 7) : 9.8454

Aromaticity : 11.42

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 0.5217

hydrophobic moment : 0.1959

Missing amino acid : A,C,E,G,Y

Most occurring amino acid : R

Most occurring amino acid frequency : 8

Least occurring amino acid : M

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (22., 20, 31.)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CCCNC(=N)N)[C@@H](C)CC)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C(C)C)[C@@H](C)O

Secondary Structure :

Method Prediction
GOR HHHHHHHHHHHHHHHHHHHTTTTTTTEEEEETTCC
Chou-Fasman (CF) CEEEEECCHHHHHHHHHCCCCCCEEEEECCCCCCC
Neural Network (NN) CCHHHHHHHHHHHHHCCCCCCCCCHHHCCHCCCCC
Joint/Consensus CCHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCC

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id :

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Not available

CancerPPD2 ID: 7740

Reference

Literature