dbacp08380
General Description
Peptide name : IDP-LS13
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : RKRRNDLRSRFLALRDQ
Peptide length: 17
C-terminal modification: Linear
N-terminal modification : Free
Non-natural peptide information: -(CH2)6-CH=CH-(CH2)3
Activity Information
Assay type : MTT/Alamamar-Blue/Hexosaminidase activity test
Assay time : 48-72 h
Activity : EC50 ~ 10 μM
Cell line : MCF-7
Cancer type : Breast Cancer
Other activity : Anticancer
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 2200.5102 Dalton
Aliphatic index : 0.747
Instability index : 129.376
Hydrophobicity (GRAVY) : -1.747
Isoelectric point : 12
Charge (pH 7) : 4.7613
Aromaticity : 5.882
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 0.4167
hydrophobic moment : -0.310
Missing amino acid : C,E,G,H,I,M,P,T,V,W,Y
Most occurring amino acid : R
Most occurring amino acid frequency : 6
Least occurring amino acid : K
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (29., 23., 23.)
SMILES Notation: CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHTTTTHHHHHHHHHHT |
| Chou-Fasman (CF) | CCCHHHHEEHHHHHCCC |
| Neural Network (NN) | CCCCCCCHHHHHHHCCC |
| Joint/Consensus | CCCCCCHHHHHHHHCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7744