dbacp08390
General Description
Peptide name : IDP-LLCb01
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : RRRRRRRSKAPKVVILSKALEYLQA
Peptide length: 25
C-terminal modification: Linear
N-terminal modification : Free
Non-natural peptide information:
Activity Information
Assay type : MTT/Alamamar-Blue/Hexosaminidase activity test
Assay time : 48-72 h
Activity : EC50 ~ 5 μM
Cell line : NCl-H187
Cancer type : Lung Cancer
Other activity : Anticancer
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 3051.6444 Dalton
Aliphatic index : 0.976
Instability index : 189.7
Hydrophobicity (GRAVY) : -1
Isoelectric point : 12
Charge (pH 7) : 8.7588
Aromaticity : 4
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 0.6667
hydrophobic moment : 0.1307
Missing amino acid : C,D,F,G,H,M,N,T,W
Most occurring amino acid : R
Most occurring amino acid frequency : 7
Least occurring amino acid : P
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (40, 12, 28)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | HHHHHHTTTCCHEEEEHHHHHHHHH |
| Chou-Fasman (CF) | HHHHCCCCCCEEEEEHHHHHHHCCC |
| Neural Network (NN) | HHCCCCCCCCCHHHHHHHHHHHHHH |
| Joint/Consensus | HHHHCCCCCCCCEEEHHHHHHHHHH |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7754