dbACP: A Comprehensive Database of Anti-Cancer Peptides

dbacp08390

General Description

Peptide name : IDP-LLCb01

Source/Organism : Synthetic

Linear/Cyclic : Linear

Chirality : L

Sequence Information

Sequence : RRRRRRRSKAPKVVILSKALEYLQA

Peptide length: 25

C-terminal modification: Linear

N-terminal modification : Free

Non-natural peptide information:

Activity Information

Assay type : MTT/Alamamar-Blue/Hexosaminidase activity test

Assay time : 48-72 h

Activity : EC50 ~ 5 μM

Cell line : NCl-H187

Cancer type : Lung Cancer

Other activity : Anticancer

Physicochemical Properties

Amino acid composition bar chart :

Molecular mass : 3051.6444 Dalton

Aliphatic index : 0.976

Instability index : 189.7

Hydrophobicity (GRAVY) : -1

Isoelectric point : 12

Charge (pH 7) : 8.7588

Aromaticity : 4

Molar extinction coefficient (cysteine, cystine): (0, 0)

Hydrophobic/hydrophilic ratio : 0.6667

hydrophobic moment : 0.1307

Missing amino acid : C,D,F,G,H,M,N,T,W

Most occurring amino acid : R

Most occurring amino acid frequency : 7

Least occurring amino acid : P

Least occurring amino acid frequency : 1

Structural Information

3D structure :

Secondary structure fraction (Helix, Turn, Sheet): (40, 12, 28)

SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCNC(=N)N)C(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)O

Secondary Structure :

Method Prediction
GOR HHHHHHTTTCCHEEEEHHHHHHHHH
Chou-Fasman (CF) HHHHCCCCCCEEEEEHHHHHHHCCC
Neural Network (NN) HHCCCCCCCCCHHHHHHHHHHHHHH
Joint/Consensus HHHHCCCCCCCCEEEHHHHHHHHHH

Molecular Descriptors and ADMET Properties

Molecular Descriptors: Click here to download

ADMET Properties: Click here to download

Cross Referencing databases

Pubmed Id :

Uniprot : Not available

PDB : Not available

CancerPPD : Not available

ApIAPDB : Not available

CancerPPD2 ID: 7754

Reference

Literature