dbacp08413
General Description
Peptide name : IDP-Lb06
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : SKAPKVVILSKALEYL
Peptide length: 16
C-terminal modification: Linear
N-terminal modification : Free
Non-natural peptide information: -(CH2)6-CH=CH-(CH2)3
Activity Information
Assay type : MTT/Alamamar-Blue/Hexosaminidase activity test
Assay time : 48-72 h
Activity : EC50 ~ 12.5 μM
Cell line : NCl-H510A
Cancer type : Lung Cancer
Other activity : Anticancer
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 1759.1374 Dalton
Aliphatic index : 1.462
Instability index : 28.1438
Hydrophobicity (GRAVY) : 0.5125
Isoelectric point : 9.5244
Charge (pH 7) : 1.459
Aromaticity : 6.25
Molar extinction coefficient (cysteine, cystine): (0, 0)
Hydrophobic/hydrophilic ratio : 1.2857
hydrophobic moment : -0.158
Missing amino acid : C,D,F,G,H,M,N,Q,R,T,W
Most occurring amino acid : K
Most occurring amino acid frequency : 3
Least occurring amino acid : P
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (56., 18., 43.)
SMILES Notation: CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CO)C(C)C)C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | TTCCHEEEHHHHHHHH |
| Chou-Fasman (CF) | CCCEEEEEHHHHHCCC |
| Neural Network (NN) | CCCCHHHHHHHHHHHH |
| Joint/Consensus | CCCCCEEEHHHHHHHH |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7777