dbacp08417
General Description
Peptide name : 5-2C
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : NYPQRPCRGDKGPDC
Peptide length: 15
C-terminal modification: Linear
N-terminal modification : Amidation
Non-natural peptide information:
Activity Information
Assay type : MTT assay
Assay time : 48-h
Activity : IC50 = 0.781 μM
Cell line : U343
Cancer type : Glioblastoma
Other activity : Antimicrobial
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 1705.8728 Dalton
Aliphatic index : 0
Instability index : 16.2067
Hydrophobicity (GRAVY) : -1.92
Isoelectric point : 8.0453
Charge (pH 7) : 0.7405
Aromaticity : 6.666
Molar extinction coefficient (cysteine, cystine): (2, 1)
Hydrophobic/hydrophilic ratio : 0.875
hydrophobic moment : -0.229
Missing amino acid : A,E,F,H,I,L,M,S,T,V,W
Most occurring amino acid : P
Most occurring amino acid frequency : 3
Least occurring amino acid : N
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (6.6, 53., 6.6)
SMILES Notation: N=C(N)NCCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CC(N)=O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | CCTCCCCTTTTCCCC |
| Chou-Fasman (CF) | CCCCCCCCCCCCCCC |
| Neural Network (NN) | CCCCCCCCCCCCCCC |
| Joint/Consensus | CCCCCCCCCCCCCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7790