dbacp08432
General Description
Peptide name : hBD3-3 M2
Source/Organism : Synthetic
Linear/Cyclic : Linear
Chirality : L
Sequence Information
Sequence : GKCSTRGRKMCRRKK
Peptide length: 15
C-terminal modification: Linear
N-terminal modification : Free
Non-natural peptide information:
Activity Information
Assay type : Annexin V/ PI staining assay
Assay time : 8-h
Activity : Inhibition in growth by apoptosis as cells positive for annexin V formed 50% of test group
Cell line : MDA-MB-231
Cancer type : Breast Cancer
Other activity : Anticancer
Physicochemical Properties
Amino acid composition bar chart :
Molecular mass : 1795.2129 Dalton
Aliphatic index : 0
Instability index : 57.9333
Hydrophobicity (GRAVY) : -1.933
Isoelectric point : 11.582
Charge (pH 7) : 7.7363
Aromaticity : 0
Molar extinction coefficient (cysteine, cystine): (2, 1)
Hydrophobic/hydrophilic ratio : 0.5
hydrophobic moment : -0.514
Missing amino acid : A,D,E,F,H,I,L,N,P,Q,V,W,Y
Most occurring amino acid : K
Most occurring amino acid frequency : 4
Least occurring amino acid : S
Least occurring amino acid frequency : 1
Structural Information
3D structure :
Secondary structure fraction (Helix, Turn, Sheet): (33., 20, 6.6)
SMILES Notation: CSCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CCCCN)NC(=O)CN)[C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Secondary Structure :
| Method | Prediction |
|---|---|
| GOR | TTCCCTTHHHHHHTT |
| Chou-Fasman (CF) | CEEEECHHHHHHCCC |
| Neural Network (NN) | CCCCCCCCHHHHCCC |
| Joint/Consensus | CCCCCCCHHHHHCCC |
Molecular Descriptors and ADMET Properties
Molecular Descriptors: Click here to download
ADMET Properties: Click here to download
Cross Referencing databases
Pubmed Id :
Uniprot : Not available
PDB : Not available
CancerPPD : Not available
ApIAPDB : Not available
CancerPPD2 ID: 7807