15 result(s) have been found!
| Accession | Name | Sequence | Source/Organism | Mechanism | Assay Type | Cell Line | Cancer Type | Activity |
|---|---|---|---|---|---|---|---|---|
| dbacp00320 | [A18K]OCN-3N | GIFDVLKNLAKGVITSLKS | Derivatives of ocellatin-3N | Membranolytic mechanism | Not specified | MDA-MB-231 | Breast adenocarcinoma | LC50 : 12-20 μM |
| dbacp00434 | [D4K,A18K]OCN-3N | GIFKVLKNLAKGVITSLKS | Derivatives of ocellatin-3N | Membranolytic mechanism | Not specified | MDA-MB-231 | Breast adenocarcinoma | LC50 : 12-20 μM |
| dbacp00437 | [D4K]OCN-3N | GIFKVLKNLAKGVITSLAS | Derivatives of ocellatin-3N | Not specified | Lactate dehydrogenase (LDH) assay | MDA-MB-231 | Breast adenocarcinoma | LC50 : 12-20 μM |
| dbacp01007 | Alyteserin-2 | ILGKLLSTAAGLLSNL | Common midwife toad | Cell penetration | Cytotoxicity assay | MDA-MB-231 | Breast adenocarcinoma | LC50 : 20 µM |
| dbacp01974 | Brevinin-2R | KLKNFAKGVAQSLLNKASCKLSGQC | Skin, Marsh frog, Europe | Activates the lysosomal-mitochondrial death pathway; Involves autophagy-like cell death | MTT-assay | MCF-7 | Breast adenocarcinoma | LD50 : 10 – 15μg/ml |
| dbacp01975 | Brevinin-2R | KLKNFAKGVAQSLLNKASCKLSGQC | Skin, Marsh frog, Europe | Activates the lysosomal-mitochondrial death pathway; Involves autophagy-like cell death | MTT-assay | MCF-7 | Breast adenocarcinoma | LD50 : 20 – 25 μg/ml |
| dbacp01976 | Brevinin-2R | KLKNFAKGVAQSLLNKASCKLSGQC | Skin, Marsh frog, Europe | Activates the lysosomal-mitochondrial death pathway; Involves autophagy-like cell death | MTT-assay | MCF-7 | Breast adenocarcinoma | LD50 : 30 – 40 μg/ml |
| dbacp01983 | Brevinin-2R | KLKNFAKGVAQSLLNKASCKLSGQC | Skin, Marsh frog, Europe | Activates the lysosomal-mitochondrial death pathway; Involves autophagy-like cell death | MTT-assay | MCF-7 | Breast adenocarcinoma | LD50 : 10 – 15 µg/ml |
| dbacp02481 | ChMAP-28 | GRFKRFRKKLKRLWHKVGPFVGPILHY | Domestic goat | Cause cell membrane permeability; Induce necrotic death | Cytotoxic Activity assay, Lactate dehydrogenase (LDH)-Releaseassay, MTT assay | SKBR-3 | Human breast adenocarcinoma | IC50 : 5.63 ± 1.05μM |
| dbacp02656 | Dermaseptin-B2 | GLWSKIKEVGKEAAKAAAKAAGKAALGAVSEAV | Giant leaf frog | Immunomodulatory properties | Cytotoxicity assays, Cell Titer-Glo Luminescent Cell viability assay | MDA-MB-231 | Breast adenocarcinoma | LC50 : < 12 μM |
| dbacp02956 | Figainin 2BN | FLGVALKLGKVLGKALLPLASSLLHSQ | Norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Trinidad, South America | Cell membrane penetration | Not specified | MDA-MB-231 | Breast adenocarcinoma | LC50 : 7-14 µM |
| dbacp05556 | Picturin 1BN | GIFKDTLKKVVAAVLTTVADNIHPK | Norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Trinidad, South America | Cell membrane penetration | Not specified | MDA-MB-231 | Breast adenocarcinoma | LC50 : 7 - 14 µM |
| dbacp05559 | Picturin 2BN | GLMDMLKKVGKVALTVAKSALLP | Norepinephrine-stimulated skin secretion, the Giant Gladiator Treefrog, the Rusty Treefrog, Trinidad, South America | Cell membrane penetration | Not specified | MDA-MB-231 | Breast adenocarcinoma | LC50 : 7 - 14 µM |
| dbacp05677 | Ps-1Pb | IKIPSFFRNILKKVGKEAVSLIAGALKQS | Merlin's dwarf gray frog | Immunomodulatory properties | Cytotoxicity assays, CellTiter-Glo Luminescent cell viability assay | MDA-MB-231 | Breast adenocarcinoma | LC50 : < 12 μM |
| dbacp05680 | Ps-2Pa | GIFPIFAKLLGKVIKVASSLISKGRTE | Merlin's dwarf gray frog | Immunomodulatory properties | Cytotoxicity assays, CellTiter-Glo Luminescent cell viability assay | MDA-MB-231 | Breast adenocarcinoma | LC50 : < 12 μM |