27 result(s) have been found!
| Accession | Name | Sequence | Source/Organism | Mechanism | Assay Type | Cell Line | Cancer Type | Activity |
|---|---|---|---|---|---|---|---|---|
| dbacp07054 | Temporin-PKE | FLPLIIGALSSLLPKIF | skin secretion of Pelophylax kl. esculentus | Charge-optimized membranolysis induces apoptosis. | MTT assay | H-157 | Lung Cancer | IC50 = 17.40 μM |
| dbacp07059 | Temporin-PKE-2K | FLPLIIGKLSSLLPKIF | Synthetic | Charge-optimized membranolysis induces apoptosis. | MTT assay | H-157 | Lung Cancer | IC50 = 2.78 μM |
| dbacp07064 | Temporin-PKE-K12 | FLPLIIGALSSKLPKIF | Synthetic | Charge-optimized membranolysis induces apoptosis. | MTT assay | H-157 | Lung Cancer | IC50 = 24.03 μM |
| dbacp07069 | Temporin-PKE-3K | FLPKIIGKLSSLLPKIF | Synthetic | Charge-optimized membranolysis induces apoptosis. | MTT assay | H-157 | Lung Cancer | IC50 = 3.29 μM |
| dbacp07074 | Temporin-PKE-4K | FLPKIIGKLSSKLPKIF | Synthetic | Charge-optimized membranolysis induces apoptosis. | MTT assay | H-157 | Lung Cancer | IC50 = 27.76 μM |
| dbacp07079 | Temporin-PKE-i | FLPLIIGALSSLLPKiF | Synthetic | Charge-optimized membranolysis induces apoptosis. | MTT assay | H-157 | Lung Cancer | IC50 = 2.94 μM |
| dbacp07084 | Temporin-PKE-3i | FLPLiiGALSSLLPKiF | Synthetic | Charge-optimized membranolysis induces apoptosis. | MTT assay | H-157 | Lung Cancer | IC50 = 71.18 μM |
| dbacp07107 | Nigrocin-M1 | GLLGKILGAGKKVLLGVSGLL | Synthetic | Membrane disruption mediates selective cytotoxicity. | MTT assay | H-157 | Non-small cell lung cancer | IC50 = 24 μM |
| dbacp07261 | t-DPH1-K4 | GLWKKIKNVAAAAGKAALGAL | Analogue of t-DPH1 | Membrane disruption induces apoptotic signaling. | MTT assay | H-157 | Lung Cancer | IC50 = 6.143 μM |
| dbacp07265 | t-DPH1-5K | GLWKKIKNVAKAAGKAALGAL | Analogue of t-DPH1 | Membrane disruption induces apoptotic signaling. | MTT assay | H-157 | Lung Cancer | IC50 = 1.546 μM |
| dbacp07269 | t-DPH1-6K | GLWKKIKNVAKAAGKAAKGAL | Analogue of t-DPH1 | Membrane disruption induces apoptotic signaling. | MTT assay | H-157 | Lung Cancer | IC50 = 88.28 μM |
| dbacp07273 | t-DPH1-6KW | WLWKKIKNVAKAAGKAAKGAL | Analogue of t-DPH1 | Membrane disruption induces apoptotic signaling. | MTT assay | H-157 | Lung Cancer | IC50 = 427.3 μM |
| dbacp07337 | Temporin-HLa | FFPLIFGALSSILPKIL | Hylarana latouchii | Membrane disruption | MTT assay | H-157 | Lung Cancer | IC50 = 15.18 ± 2.98 μM |
| dbacp07409 | Dermaseptin-TO | ALWKDLLKNVGIAAGKAALNKVTDMVNQ | Phyllomedusa tomopterna | Membrane disruption induces cell death | MTT assay | H-157 | Lung Cancer | Graph Figure-7 |
| dbacp07503 | Brevinin-1Ha | FALGAVTCLIRTKCKVLPKLF | Analogue of Brevinin-1H | α-helix enhances antimicrobial, anticancer activity | MTT assay | H-157 | Lung Cancer | IC50 = 278.9 µM |
| dbacp07507 | Brevinin-1HY | FALGAVTKVLYKLFCLITRKC | Analogue of Brevinin-1H | α-helix enhances antimicrobial, anticancer activity | MTT assay | H-157 | Lung Cancer | IC50 = 2.811 µM |
| dbacp07512 | Dermaseptin-PP | ALWKDMLKGIGKLAGKAALGAVKTLV | Phyllomedusa palliata | Membrane disruption triggers dual apoptosis | MTT assay | H-157 | Lung Cancer | IC50 = 1.55 μM |
| dbacp07516 | Dermaseptin-PP | ALWKDMLKGIGKLAGKAALGAVKTLV | Phyllomedusa palliata | Membrane disruption triggers dual apoptosis | LDH leakage assay | H-157 | Lung Cancer | 80% LDH release at 10−4 M |
| dbacp07851 | Dermaseptin-PT9 | GLWSKIKDAAKTAGKAALGFVNEMV | Phyllomedusa tarsius | Membrane disruption and cationic enhancement | MTT assay | H-157 | Lung Cancer | IC50 = 25.51 µM |
| dbacp07856 | K8, 23-DPT9 | GLWSKIKKAAKTAGKAALGFVNKMV | Synthetic | Membrane disruption and cationic enhancement | MTT assay | H-157 | Lung Cancer | IC50 = 9.88 µM |
| dbacp07952 | S-24-R2PLx | GIMDTVKNAAKNLAGQLLDKLKCSITAC | Synthetic Analogue of Ranatuerin-2PLx | R2PLx induces caspase-dependent apoptosis | MTT assay | H-157 | Lung Cancer | IC50 = 58.18 µM |
| dbacp07956 | DP-2 | GRKKRRQRRRGALWKSLLKNVGKA | Synthetic | DRS-DU-1 induces selective tumor cytotoxicity | MTT assay | H-157 | Lung Cancer | IC50 = 3.21 μM |
| dbacp07989 | K5, 17-DPS3 | ALWKKILKNAGKAALNKINQIVQ | Analogue of Dermaseptin-PS3 | Enhanced cationicity/hydrophobicity increases cytotoxicity | MTT assay | H-157 | Lung Cancer | IC50 = 18.20 μM |
| dbacp07991 | L10, 11-DPS3 | ALWKDILKNLLKAALNEINQIVQ | Analogue of Dermaseptin-PS3 | Enhanced cationicity/hydrophobicity increases cytotoxicity | MTT assay | H-157 | Lung Cancer | IC50 = 0.12 μM |
| dbacp08064 | Temporin-PE | FLPIVAKLLSGLL | Pelophylax kl. esculentus | Modulates membrane interactions | MTT assay | NCI-H-157 | Lung Cancer | IC50 = 34.56 μM |
| dbacp08068 | temporin-PEa | FLYIVAKLLSGLL | Synthetic analog of Temporin-PE | Modulates membrane interactions | MTT assay | NCI-H-157 | Lung Cancer | IC50 = 3.398 μM |
| dbacp08072 | temporin-PEb | FLPIVAKLLSGLLGRKKRRQRRR | Synthetic analog of Temporin-PE | Modulates membrane interactions | MTT assay | NCI-H-157 | Lung Cancer | IC50 = 3.464 μM |