21 result(s) have been found!
| Accession | Name | Sequence | Source/Organism | Mechanism | Assay Type | Cell Line | Cancer Type | Activity |
|---|---|---|---|---|---|---|---|---|
| dbacp04794 | N29D | PDEDAINDALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | > 100% cell viability at 5 µM |
| dbacp04795 | N29D | PDEDAINDALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | 60% cell viability at 50 µM |
| dbacp04800 | N29D | PDEDAINDALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | > 100% cell viability at 5 µM |
| dbacp04801 | N29D | PDEDAINDALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | 60% cell viability at 50 µM |
| dbacp04806 | N29N | PDEDAINNALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | 100% cell viability at 5 µM |
| dbacp04807 | N29N | PDEDAINNALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | 40% cell viability at 50 µM |
| dbacp04812 | N29N | PDEDAINNALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | 100% cell viability at 5 µM |
| dbacp04813 | N29N | PDEDAINNALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | 40% cell viability at 50 µM |
| dbacp04818 | N29N | PDEDAINNALNKVCSTGRRQRSICKQLLKK | Synthetic peptide | Apoptotic inducing | Cell viability assay | SW-480 | Colon cancer | MIC : 5 µM |
| dbacp04867 | NK-2 | KILRGVCKKIMRTFLRRISKDILTGKK | NK-lysin | Cell membrane disintegration | PI-uptake assay | SW-480 | Leukemia cancer | LD50 : 1-4 µM |
| dbacp06737 | Aurein 1.2_mutant (Aurm) | GLFDIIKKIIKSF | Synthetic | Necrotic activity via cell membrane lysis and apoptotic activity through disrupting mitochondrial membrane | MTT assay | SW-480 | Colon Cancer | 51.63% cell viability |
| dbacp06739 | Aurein 1.2_R5 (R5-Aur) | RRRRRGLFDIIKKIAESF | Synthetic | Necrotic activity via cell membrane lysis and apoptotic activity through disrupting mitochondrial membrane | MTT assay | SW-480 | Colon Cancer | 43.89% cell viability |
| dbacp06741 | Aurein 1.2_mutant_R5 (R5-Aurm) | RRRRRGLFDIIKKIIKSF | Synthetic | Necrotic activity via cell membrane lysis and apoptotic activity through disrupting mitochondrial membrane | MTT assay | SW-480 | Colon Cancer | 40.62% cell viability |
| dbacp07085 | HB43 | FAKLLAKLAKKLL | Synthetic | Motif-driven membrane insertion triggers cytotoxicity | AlamarBlue assay | SW-480 | Colon Cancer | IC50 = 12 ± 4 μM |
| dbacp07089 | HB43-mut2 | FAKLLAKLAKLLK | Synthetic | Motif-driven membrane insertion triggers cytotoxicity | AlamarBlue assay | SW-480 | Colon Cancer | IC50 = 34 ± 2 μM |
| dbacp07093 | HB43-mut3 | FAKLLAKLARRLL | Synthetic | Motif-driven membrane insertion triggers cytotoxicity | AlamarBlue assay | SW-480 | Colon Cancer | IC50 = 8 ± 1 μM |
| dbacp07287 | P264-G274 | PARDVLNTTSG | Parasporin-2Aa1 | h-APN receptor–mediated apoptosis induction. | Sulforhodamine B assay | SW-480 | Colorectal Cancer | EC50 = 90.98 ± 0.75 µM |
| dbacp07289 | Loop1-PS2Aa | NNETYFNAVKP | Parasporin-2Aa1 | h-APN receptor–mediated apoptosis induction. | Sulforhodamine B assay | SW-480 | Colorectal Cancer | EC50 = 23.76 ± 1.25 µM |
| dbacp07291 | Loop2-PS2Aa | TYFNAVKPPITA | Parasporin-2Aa1 | h-APN receptor–mediated apoptosis induction. | Sulforhodamine B assay | SW-480 | Colorectal Cancer | EC50 = 92.99 ± 0.98 µM |
| dbacp07293 | Loop1-HCoV-229E | FKPQSGGGKCF | Alphacoronavirus (HCoV-229E) | h-APN receptor–mediated apoptosis induction. | Sulforhodamine B assay | SW-480 | Colorectal Cancer | EC50 = 125.0 ± 1.32 µM |
| dbacp07294 | A4W-GGN5 | FLGWLFKVASK | Gaegurin 5 | h-APN receptor–mediated apoptosis induction. | Sulforhodamine B assay | SW-480 | Colorectal Cancer | EC50 = 98.63 ± 1.17 µM |