41 result(s) have been found!
| Accession | Name | Sequence | Source/Organism | Mechanism | Assay Type | Cell Line | Cancer Type | Activity |
|---|---|---|---|---|---|---|---|---|
| dbacp00725 | 6,7-dimethyl-8-ribityllumazine synthase 2 | MNQSCPNKTSFKIAFIQARWHADIVDEARKSFVAELAAKTGGSVEVEIFDVPGAYEIPLHAKTLARTGRYAAIVGAAFVIDGGIYRHDFVATAVINGMMQVQLETEVPVLSVVLTPHHFHESKEHHDFFHAHFKVKGVEAAHAALQIVSERSRIAALV | Not found | Apoptosis inducing | Apoptosis assay | B16 | Melanoma | Not found |
| dbacp01596 | BF-30 | KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF | Banded krait | Cytoplasmic membrane permeabilization and DNAspecified-binding | Lactate dehydrogenase release assay, DNA retardation assay, Real-time PCR, Western blot, wound healing assay, and chick embryo chorioallantoic membrane assay | B16F10 | Human Colon cancer | IC50 : 7.3 μM |
| dbacp01597 | BF-30 | KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF | Banded krait | Cytoplasmic membrane permeabilization and DNAspecified-binding | Lactate dehydrogenase release assay, DNA retardation assay, Real-time PCR, Western blot, wound healing assay, and chick embryo chorioallantoic membrane assay | B16 | Human Cervical cancer | IC50 : 13.9 μM |
| dbacp01609 | Bim | EIWIAQELRRIGDEFNAYYAR | BH3-only, Direct activators, BIM analogues | Inducing apoptosis | Not specified | B16 | Melanoma | Not found |
| dbacp01951 | Brevinin-1RL1 | FFPLIAGLAARFLPKIFCSITKRC | Not found | Inducing apoptosis | Cell death assay | B16F10 | Not specified | IC50 : 6.65 ± 0.33 μM |
| dbacp02270 | Camel | KWKLFKKIGAVLKVL | Ceropin-Melittin hybrid | Cell swelling and rupture of the plasma membrane | MTT/MTS assay | B16-F10 | Skin cancer | LC50 : 1.75 µM |
| dbacp02480 | ChMAP-28 | GRFKRFRKKLKRLWHKVGPFVGPILHY | Domestic goat | Cause cell membrane permeability; Induce necrotic death | Cytotoxic Activity assay, Lactate dehydrogenase (LDH)-Releaseassay, MTT assay | B16F1 | Murine melanoma | IC50 : 4.82 ± 1.01μM |
| dbacp02813 | Drosophila Antennapedia homodomain PFV | CALNNPFVYLI | Fruit fly homodomain PFV | Cell membrane disintegration | SPR assay | B16 | Mouse melanoma | Not found |
| dbacp02930 | Figainin 1 | FIGTLIPLALGALTKLFK | Chaco tree frog | Membrane disruption and cell lysis | MTT/MTS assay | B16F10 | Leukemia | IC50 : 10.5 µM |
| dbacp02936 | Figainin 1 | MAFLKKSLFLVLFLGLVSLSIGEEEKREEEEKNEEGANQEENAENKEKRFIGTLIPLALGALTKLFKG | Chaco tree frog | Anti-proliferative action | MTT/MTS assay | B16F10 | Skin cancer | IC50 : 10.5 µM |
| dbacp02937 | Figainin 1 | MAFLKKSLFLVLFLGLVSLSIGEEEKREEEEKNEEGANQEENAENKEKRFIGTLIPLALGALTKLFKG | Chaco tree frog | Anti-proliferative action | MTT/MTS assay | B16F10 | Breast cancer | IC50 : 10.5 µM |
| dbacp02938 | Figainin 1 | MAFLKKSLFLVLFLGLVSLSIGEEEKREEEEKNEEGANQEENAENKEKRFIGTLIPLALGALTKLFKG | Chaco tree frog | Anti-proliferative action | MTT/MTS assay | B16F10 | Cervical cancer | IC50 : 10.5 µM |
| dbacp02946 | Figainin 1 | FIGTLIPLALGALTKLFK | Skin secretions, Chaco tree frog, South America | Membrane disruption | MTT/MTS assay | B16F10 | Leukemia | IC50 : 10.5 µM |
| dbacp02949 | Figainin 2 | FLGAILKIGHALAKTVLPMVTNAFKPKQ | Skin secretions, Chaco tree frog, South America | Cell membrane interaction; Necrosis; Apoptosis | MTT/MTS assay | B16F10 | Murien melanoma | IC50 : 12.8 µM |
| dbacp02951 | Figainin 2 | MAFLKKSLFLVLFLGIVSLSVCEEEKREGEEKEEKREEEEGKEENEDGNEEHKEKRFLGAILKIGHALAKTVLPMVTNAFKPKQ | Chaco tree frog | Necrosis; Apoptosis | MTT/MTS assay | B16F10 | Skin cancer | IC50 : 12.8 µM |
| dbacp02952 | Figainin 2 | MAFLKKSLFLVLFLGIVSLSVCEEEKREGEEKEEKREEEEGKEENEDGNEEHKEKRFLGAILKIGHALAKTVLPMVTNAFKPKQ | Chaco tree frog | Necrosis; Apoptosis | MTT/MTS assay | B16F10 | Breast cancer | IC50 : 12.8 µM |
| dbacp03328 | HSP70 peptide | ACFAEKFKEAVKDYFAKFWD-GSG-TKDNNLLGRFELSG | Not found | Immune response to tumor cell recognition | Cytotoxic assay, Lactate dehydrogenase (LDH) release assay | B16OVA | Necroptotic cancer | Not found |
| dbacp03531 | L-amino acid oxidase (CC-LAAO) (LAO) (EC 1.4.3.2) | MNVFFMFSLLFLAALESCADDKNPLEEEFFEADYEEFLLIAKNGLQQTSNPKRVVIVGAGMSGLSAAYVLAKTGHEVILLEASERVGGRVSTYRNDQEGWYANLGPMRLPERHRIVREYIRKFGLQLNEFSQENENAWYFIKNIRKRVGEVNKDPGVLEYPVKPSEKGKSAPQLYRDSLQKIIEEYGRSNCSYILNKYDTYSTKDYLIKEGNLSPGAVDMVGDLLNEDSGYYVSFIESLKPDDIFAYENRFDEIVGGFDKLPTSMYQAIQEKVRLNVRVIKIQQDVKEVTVTYQTPAKNLSYVTADYVIVCTTSGAARRIKFEPPLPLKKAHALRSVHYRSGTKIFLTCTKKFWEDDGIHGGKSITDRPSRLIHYPNHNFPNGIGVLVIFTIADDADFFLALDNKTIADIVIHDLSLIHQLPKEKIRDLCYVSMIQKWSLDKYAMGGITTFTPYQFQHFSEALTAPVDRIYFAGEYTAQAHGWIDSTIKSGLTAARDVNRASENPSGIHLSNDNEL | Horned desert vip | Cytotoxic effects | MTT assay | B16F10 | Not found | IC50 : 2 µg/mL |
| dbacp03539 | L-amino-acid oxidase (BatroxLAAO) (LAO) (EC 1.4.3.2) | MNVFFTFSLLFLAALGSCADDRNPLEECFRETDYEEFLEIAKNGLSTTSNPKRVVIVGAGMSGLSAAYVLANAGHQVTVLEASERAGGRVKTYRNEKEGWYANLGPMRLPEKHRIVREYIRKFDLQLNEFSQENENAWYFIKNIRKRVGEVNKDPGVLEYPVKPSEVGKSAGQLYEESLQKAVEELRRTNCSYMLNKYDTYSTKEYLLKEGNLSPGAVDMIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDKLPTSMYQAIQEKVHLNARVIKIQQDVKEVTVTYQTSEKETLSVTADYVIVCTTSRAARRIKFEPPLPPKKAHALRSVHYRSGTKIFLTCTKKFWEDDGIHGGKSTTDLPSRFIYYPNHNFPNGVGVIIAYGIGDDANYFQALDFEDCGDIVINDLSLIHQLPKEEIQAICRPSMIQRWSLDKYAMGGITTFTPYQFQHFSEALTAPVDRIYFAGEYTAQAHGWIDSTIKSGLRAARDVNRASEIKK | Common lancehead | Inducing apoptosis | MTT assay | B16F10 | Not found | Not found |
| dbacp03600 | l3,10,13K7,8K4R2L9 | KLlRLLkkLlRLlLK | Diastereomeric peptide | Plasma membrane perturbation; Necrosis | XTT assay | B16-F10 | Skin cancer | LC50 : 2.5 µM |
| dbacp03602 | l3,4,8,10K5L7 | KlllKLKlKlLK | Diastereomeric peptide | Plasma membrane perturbation; Necrosis | XTT assay | B16-F10 | Skin cancer | LC50 : 100 µM |
| dbacp04302 | LTX-315 | KKWWKKW-Dip-K | Synthetic peptide | Necrosis | MTT/MTS assay | B16F1 | Skin cancer | IC50 : 13.3 µM |
| dbacp05094 | P7 | PLLQATLGGGS | Not found | Apoptosis inducing | WST-1 assay | B16-F10 | Skin cancer | IC50 : 1 µM |
| dbacp05241 | pentadactylin | GLLDTLKGAAKNVVGSLASKVMEKL | Not found | Inducing apoptosis | MTT assay | B16F10 | Melanoma | IC50 : 25.7 µM |
| dbacp05441 | Peptide-20 | CSSRTMHHC | Synthetic Peptide | Inducing apoptosis | MTT/MTS assay | B16F10-Nex 2 | Skin cancer | At 100 µM 50% viablity |
| dbacp05505 | PHP | ITCPQVTQSLAPCVPYLISG | Plant sources | Inducing apoptosis | MTT assay | B16 | Not found | IC50 : 1.47 µM |
| dbacp05820 | R8 | CALRRRRRRRR | Not found | Cell membrane disintegration | SPR assay | B16 | Mouse Melanoma | Not found |
| dbacp05917 | Raniseptin-3 | AWLDKLKSIGKVVGKVAIGVAKNLLNPQ | Skin secretion, Chaco tree frog, South America | Disrupting cancer cell membranes | MTT and LDH assay | B16F10 | Murine melanoma | IC50 : 6.56 μM |
| dbacp05919 | Raniseptin-6 | ALLDKLKSLGKVVGKVALGVVQNYLNPRQ | Skin secretion, Chaco tree frog, South America | Disrupting cancer cell membranes | MTT and LDH assay | B16F10 | Murine melanoma | IC50 : 8.69 μM |
| dbacp05966 | RGD-tachyplesin | CRGDCGGKWCFRVCYRGICYRRCR | Not found | Inducing apoptosis | Not specified | B16 | Prostate cancer | Not found |
| dbacp06157 | StigA16 | FFKLIPKLVKGLISAF | Amino acid substitution, amino acid truncation, animal-derived, natural derivative | Disruption of cell membrane | MTT assay | B16 | Human pancreas adenocarcinoma | IC 50 : 13.01 μM |
| dbacp06162 | StigA6 | FFSLIPKLVKGLISAFK | Amino acid substitution, animal-derived, natural derivative | Disruption of cell membrane | MTT assay | B16 | Human pancreas adenocarcinoma | IC 50 : 14.01 μM |
| dbacp06202 | TAT-Bim (145-165) | RKKRRQ(orn)RRREIWIAQELRRIGDEFNAYYAR | BH3-only, Direct activators, BIM analogues | Inducing apoptosis | Not specified | B16 | Melanoma | Not found |
| dbacp06404 | Tyroserleutide | YSL | Synthetic Peptide | Necrosis; Immune regulation | MTT/MTS assay | B16-F10 | Skin cancer | 49.4% Cytotoxic at 0.1 µg/ml |
| dbacp06405 | Tyroserleutide | YSL | Synthetic Peptide | Necrosis; Immune regulation | MTT/MTS assay | B16-F10 | Skin cancer | 51.2% Cytotoxic at 1 µg/ml |
| dbacp06406 | Tyroserleutide | YSL | Synthetic Peptide | Necrosis; Immune regulation | MTT/MTS assay | B16-F10 | Skin cancer | 53.0% Cytotoxic at 10 µg/ml |
| dbacp06407 | Tyroserleutide | YSL | Synthetic Peptide | Necrosis; Immune regulation | MTT/MTS assay | B16-F10 | Skin cancer | 61.2% Cytotoxic at 100 µg/ml |
| dbacp06735 | NKL-WT | KLKSKLMVVCNKIGLLKSLCRKFVKSH | Trematomus bernacchii | Apoptosis inducing | luciferase-based ATPlite assay | B16-F10 | Skin Cancer | ATP level = 0.753 ± 0.254 at 40 μM |
| dbacp06736 | NKL-MUT | KLKSKLMVVANKIGLLKSLARKFVKSH | Trematomus bernacchii | Apoptosis inducing | luciferase-based ATPlite assay | B16-F10 | Skin Cancer | ATP level = 0.023 ± 0.007 at 40 μM |
| dbacp07239 | RB4 | MADSERLSAPGCWAACTNFSRTRK | Derived from protein PLP2 | F-actin modulation induces necrotic death. | MTT assay | B16-F10-Nex 2 | Skin Cancer | EC50 = 0.263 ± 0.585 mol/L × 10-3 |
| dbacp07493 | Figainin 1 | FIGTLIPLALGALTKLFK | Boana raniceps | Membrane disruption, α-helix mediated | MTT assay | B16-F10 | Skin Cancer | IC50 = 10.5 µM |